You can do this route independently. You can do it as a teahouse trek.
Here’s an independent trip report by Sathya:
9th – 27th Oct 2012
Lonely planet : Trekking in the Nepal Himalayas.
Note : The LP guide refers to this trek as a camping trek as of 2009 (when it was published). This trek can currently be done as a tea-house trek. The lodges in this trek are very rustic and there are just 1 or 2 lodges that are open in each of the villages en route. Do not expect anything more than dal-bhat at these lodges. …
Permits – One just needs a TIMS permit for this trek. …
Getting to/from the trailhead (Khandbari):
This is as arduous a task as the trek itself.
Coming from Kathmandu : The best way (most comfortable) to get to this is to take a flight (Buddha air) to Tumlingtar from Kathmandu. … Khandbari is less than an hour’s drive. …
Makalu Base Camp trek
13th Oct : Khandbari to RaniDunga (by jeep) and from there to Num and halfway to Sedua (trek)
14th Oct : Sedua to Tashigaon (2070 M)
15th Oct : Tashigaon to Khongma (3560 M)
16th Oct : Khongma to Dobato via Ghuguru/Tutu La (4050 M), Shipton La (4216 M) and Keke La (4150 M)
17th Oct : Dobato to Yangle Kharka (3600 M)
18th Oct : Yangle Kharka to Langma Le (4400 M)
19th Oct : Langma Le to Makalu Base Camp (~4700 M)
20th Oct : Makalu Base Camp to Yangle Kharka
21st Oct : Yangle Kharka to Khongma
22nd Oct : Khongma to Num
23rd Oct : Num to Khandbari